Abstract | BACKGROUND: METHODS AND RESULTS: We used United Network for Organ Sharing registry to identify adults who were listed for heart transplantation between 2000 and 2015 for radiation-induced restrictive cardiomyopathy (RT-RCM) and compared their characteristics and transplant outcomes to restrictive cardiomyopathies of other etiologies (RCM) and all other patients listed for heart transplantation (others). Of 45,041 adults, 87 (0.2%) of transplantations were due to RT-RCM, 1049 (2.3%) were due to RCM, and there were 44,805 others. Compared with patients with RCM and other etiologies, those with RT-RCM were younger, less likely male, more likely to be white, listed as status 2, and were also more likely to have had previous cardiac surgeries. Posttransplant, patients with RT-RCM had longer lengths of stay and higher early mortality; 1-, 3-, and 5-year cumulative survival were as follows for RT-RCM (76%, 66%, 58%), RCM (88%, 79%, 73%; P = .025 compared with RT-RCM), and other etiologies (88%, 82%, 76%; P = .012 compared with RT-RCM). CONCLUSIONS: Patients with end-stage RT-RCM are predominantly younger females with previous cardiac surgeries. Posttransplantation survival in these patients appears to be lower than in those with other forms of restrictive cardiomyopathies and heart failure etiologies, mainly because of higher early postoperative mortality. Further studies are needed to confirm these findings.
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Authors | Sadeer G Al-Kindi, Guilherme H Oliveira |
Journal | Journal of cardiac failure
(J Card Fail)
Vol. 22
Issue 6
Pg. 475-8
(Jun 2016)
ISSN: 1532-8414 [Electronic] United States |
PMID | 27084524
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Topics |
- Cardiomyopathy, Restrictive
(etiology, mortality, surgery)
- Female
- Heart Transplantation
- Humans
- Male
- Middle Aged
- Radiation Injuries
(complications)
- Registries
- Retrospective Studies
- Risk Factors
- Survival Rate
(trends)
- Treatment Outcome
- United States
(epidemiology)
- Waiting Lists
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