Deacetylravidomycin N-oxide, a new antibiotic. Taxonomy and fermentation of the producing organism and isolation, structure and biological properties of the antibiotic.

Abstract

Streptomyces ravidus S50905 was found to produce a new antibiotic, deacetylravidomycin N-oxide, together with ravidomycin and deacetylravidomycin in a culture medium containing sodium anthraquinone-beta-sulfonate. The structure of this new compound was determined from NMR and mass spectrometric data, and further confirmed by chemical synthesis from deacetylravidomycin. Deacetylravidomycin N-oxide was antitumor active against P388 leukemia and Meth A fibrosarcoma in a wide range of doses, and considerably less toxic than deacetylravidomycin. Its antibacterial activity was less potent than deacetylravidomycin. Ravidomycin N-oxide was also synthesized from ravidomycin and its biological properties were tested.

• Authors: T Narita, M Matsumoto, K Mogi, K Kukita, R Kawahara, T Nakashima
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 42 Issue 3 Pg. 347-56 (Mar 1989) ISSN: 0021-8820 [Print] England
• PMID: 2708127 (Publication Type: Journal Article)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• deacetylravidomycin N-oxide

Topics

• Aminoglycosides
• Animals
• Anti-Bacterial Agents (isolation & purification, pharmacology)
• Chemical Phenomena
• Chemistry
• Fermentation
• Mice
• Microbial Sensitivity Tests
• Neoplasms, Experimental (drug therapy)
• Streptomyces (classification, metabolism)