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Leydig cell tumor of the ovary associated with endometrial carcinoma and containing 17 beta-hydroxysteroid dehydrogenase.

Abstract
A case of ovarian Leydig cell tumor associated with adenocarcinoma of the endometrium in a 66-year-old woman is described herein, the eighth such case published. Clinically, both masculinizing and feminizing symptoms were observed: an increase in facial hair growth, slight baldness, clitoromegaly, and postmenopausal genital bleeding. Three biopsies of the endometrium during a 5-month preoperative period showed atypical hyperplasia. Surgically resected material contained a Leydig cell tumor of the left ovary and focal adenocarcinoma in atypical hyperplasia of the endometrium. Serum levels of androgens and estrogens measured by radioimmunoassay decreased after removal of the tumor. Immunohistochemical studies revealed that the Leydig cell tumor contained testosterone, estrogens, and 17 beta-hydroxysteroid dehydrogenase (HSD) in the cytoplasm. This is the first report of a Leydig cell tumor in which the localization of 17 beta-HSD was demonstrated immunohistochemically.
AuthorsR Ichinohasama, S Teshima, K Kishi, K Mukai, R Tsunematsu, H Ishii-Ohba, Y Shimosato
JournalInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 8 Issue 1 Pg. 64-71 ( 1989) ISSN: 0277-1691 [Print] United States
PMID2707954 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Estrogens
  • Testosterone
  • 17-Hydroxysteroid Dehydrogenases
Topics
  • 17-Hydroxysteroid Dehydrogenases (analysis)
  • Adenocarcinoma (metabolism, pathology)
  • Aged
  • Estrogens (blood)
  • Female
  • Humans
  • Immunohistochemistry
  • Leydig Cell Tumor (metabolism, pathology)
  • Neoplasms, Multiple Primary (metabolism, pathology)
  • Ovarian Neoplasms (metabolism, pathology)
  • Testosterone (blood)
  • Uterine Neoplasms (metabolism, pathology)

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