Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis.

Abstract

Extended spectrum β-lactamase (ESBL)-positive Escherichia coli is a major etiological organism responsible for bovine mastitis. The autoinducer 2 (AI-2) quorum sensing system is widely present in many species of gram-negative and gram-positive bacteria and has been proposed to be involved in interspecies communication. In E. coli model strains, the functional mechanisms of AI-2 have been well studied; however, in clinical antibiotic-resistant E. coli strains, whether AI-2 affects the expression of antibiotic resistance genes has not been reported. In this study, we report that exogenous AI-2 increased the antibiotic resistance of a clinical E. coli strain isolated from a dairy cow with mastitis by upregulating the expression of TEM-type enzyme in an LsrR (LuxS regulated repressor)-dependent manner.

• Authors: Ting Xue, Lumin Yu, Fei Shang, Wenchang Li, Ming Zhang, Jingtian Ni, Xiaolin Chen
• Journal: Journal of dairy science (J Dairy Sci) Vol. 99 Issue 6 Pg. 4693-4698 (Jun 2016) ISSN: 1525-3198 [Electronic] United States
• PMID: 27060825 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Bacterial Proteins
• Lactones
• N-octanoylhomoserine lactone
• beta-Lactams
• Homoserine

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Bacterial Proteins (metabolism)
• Cattle
• Escherichia coli (genetics)
• Female
• Gene Expression Regulation, Bacterial
• Homoserine (analogs & derivatives, metabolism)
• Lactones (metabolism)
• Mastitis, Bovine (microbiology)
• beta-Lactam Resistance
• beta-Lactams (pharmacology)