Abstract |
We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause.
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Authors | Jung-Ick Byun, Soon-Tae Lee, Keun-Hwa Jung, Jun-Sang Sunwoo, Jangsup Moon, Tae-Joon Kim, Jung-Ah Lim, Soyun Kim, Do-Yong Kim, Su-Hyun Han, Hyemin Jang, Hong Il Suh, A-Hyun Cho, Dong Wook Kim, Jung-Won Shin, Yong Seo Koo, Woo Chan Choi, Woong-Woo Lee, Nari Choi, Seongheon Kim, Hyunwoo Nam, Dae Lim Koo, Minah Kim, Byung Chan Lim, Jong-Hee Chae, Ki Joong Kim, Daejong Jeon, Kyung-Il Park, Ki-Young Jung, Manho Kim, Kon Chu, Sang Kun Lee |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 293
Pg. 34-38
(Apr 15 2016)
ISSN: 1872-8421 [Electronic] Netherlands |
PMID | 27049559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
Chemical References |
- Autoantibodies
- Intracellular Signaling Peptides and Proteins
- LGI1 protein, human
- Nerve Tissue Proteins
- Proteins
- Receptors, N-Methyl-D-Aspartate
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Topics |
- Age Factors
- Autoantibodies
(blood, cerebrospinal fluid)
- Brain Diseases
(epidemiology, etiology, immunology)
- Cohort Studies
- Female
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Nerve Tissue Proteins
(immunology)
- Prevalence
- Proteins
(immunology)
- Receptors, N-Methyl-D-Aspartate
(immunology)
- Registries
- Republic of Korea
(epidemiology)
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