Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.

Abstract

AIM:

The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.

MATERIALS AND METHODS:

Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol.

RESULTS:

The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity.

CONCLUSION:

We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.

• Authors: Ankit S Prajapati, Sunant K Raval, Suprita Sinha, Tapan N Varia, Parimal H Mashiyava
• Journal: Veterinary world (Vet World) Vol. 8 Issue 8 Pg. 937-40 (Aug 2015) ISSN: 0972-8988 [Print] India
• PMID: 27047180 (Publication Type: Journal Article)