Lack of effect of dietary factors on nicarbazin toxicity in broiler chicks.

Effects of dietary fat, protein, and methionine levels and the type of dietary grain in nicarbazin-containing diets on the growth response of broiler chicks were evaluated in five experiments in a factorial design. Nicarbazin at levels ranging from 100 to 200 mg/kg significantly (P less than .05) depressed weight gain and feed efficiency. Feed intake was significantly reduced only when nicarbazin was used at levels of 150 and 200 mg/kg. The latter concentration also significantly decreased water intake and water:feed ratio. Nicarbazin, at a level of 150 mg/kg, did not affect dietary metabolizable energy content or the retention of nitrogen and dry matter. A higher level of soybean oil (3.5 vs. .5 or 1.0%) did not counteract the growth-depressing effects of 100, 150, and 200 mg nicarbazin/kg. The growth-depressing effect of the highest dose also was not affected by increasing the protein level from 18.2 to 20.4%. Neither type of dietary grains (corn vs. sorghum) nor supplemental methionine level affected the toxicity of 125 mg nicarbazin/kg. Water intake and water:feed ratio were significantly increased due to elevation of dietary protein and fat levels. It was concluded that the severity of the growth-depressing effect of nicarbazin on chicks was not dependent on the levels of dietary unsaturated fat, protein, and methionine.
AuthorsI Bartov
JournalPoultry science (Poult Sci) Vol. 68 Issue 1 Pg. 145-52 (Jan 1989) ISSN: 0032-5791 [Print] UNITED STATES
PMID2704670 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbanilides
  • Dietary Fats
  • Dietary Proteins
  • Nicarbazin
  • Soybean Oil
  • Methionine
  • Animals
  • Body Weight (drug effects)
  • Carbanilides (toxicity)
  • Chickens (growth & development)
  • Dietary Fats (pharmacology)
  • Dietary Proteins (pharmacology)
  • Female
  • Male
  • Methionine (pharmacology)
  • Nicarbazin (toxicity)
  • Soybean Oil (pharmacology)

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