HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Somatostatin analogue SMS 201-995 (octreotide) as a possible solution to the dumping syndrome after gastrectomy or vagotomy.

Abstract
The dumping syndrome, which may follow partial gastrectomy or truncal vagotomy and drainage, may be refractory to treatment. The aim of this study was to determine the effect of the somatostatin analogue, SMS 201-995 (octreotide), on dumping provoked by hypertonic glucose. Ten patients with symptoms and signs of dumping were studied. After a dumping provocation test with placebo, all patients developed severe symptoms: seven patients had early dumping, two had both early and late dumping and one had late dumping alone. With either 50 or 100 micrograms SMS 201-995, the symptoms of early dumping were much reduced in all patients, and those of late dumping were completely abolished. The packed cell volume, pulse and systolic blood pressure changes of early dumping were significantly reduced by SMS 201-995 and the fall in blood glucose in patients with late dumping was abolished. SMS 201-995 may be a useful treatment for early and late dumping.
AuthorsJ N Primrose, D Johnston
JournalThe British journal of surgery (Br J Surg) Vol. 76 Issue 2 Pg. 140-4 (Feb 1989) ISSN: 0007-1323 [Print] England
PMID2702445 (Publication Type: Journal Article)
Chemical References
  • Glucose Solution, Hypertonic
  • Octreotide
Topics
  • Adult
  • Animals
  • Chick Embryo
  • Dumping Syndrome (drug therapy, physiopathology)
  • Female
  • Gastrectomy
  • Glucose Solution, Hypertonic
  • Hematocrit
  • Humans
  • Male
  • Middle Aged
  • Octreotide (therapeutic use)
  • Time Factors
  • Vagotomy

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: