Exemestane encapsulated vitamin E-TPGS-polymeric nanoparticles: preparation, optimization, characterization, and in vitro cytotoxicity assessment.

Abstract

The objective of the present study was to formulate and optimize exemestane (EXM) encapsulated vitamin E-TPGS-poly-ɛ-caprolactone based polymeric nanoparticles (TPGS-PCLNPs) for enhancing its anticancer efficacy. The 23 factorial design was employed to investigate the combined influence of formulation and process variables on properties of TPGS-PCLNPs, prepared by nanoprecipitation method. The physicochemical characterization revealed the encapsulation of EXM in amorphous form without any interaction inside spherical shaped TPGS-PCLNPs. In vitro cytotoxicity study on MCF-7 breast cancer cells exhibited enhanced cytotoxicity of EXM by encapsulating in TPGS-PCLNPs. The TPGS-PCLNPs can serve as potential delivery vehicle for EXM to improve its therapeutic efficacy.

• Authors: Brahmeshwar Mishra, Ravi Padaliya, Ravi R Patel
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 45 Issue 3 Pg. 522-534 (May 2017) ISSN: 2169-141X [Electronic] England
• PMID: 27017970 (Publication Type: Journal Article)

Chemical References

• Androstadienes
• Antineoplastic Agents, Phytogenic
• Drug Carriers
• Polyesters
• Vitamin E
• polycaprolactone
• exemestane
• tocophersolan

Topics

• Androstadienes (chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Biological Transport
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Drug Carriers
• Drug Compounding
• Drug Liberation
• Factor Analysis, Statistical
• Female
• Humans
• Hydrogen-Ion Concentration
• Kinetics
• MCF-7 Cells
• Nanoparticles (chemistry, ultrastructure)
• Particle Size
• Polyesters (chemistry, metabolism)
• Vitamin E (chemistry, metabolism)