Benzo(a)pyrene (BaP) stimulates
lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including
heparin binding-
epidermal growth factor and C-X-C motif
chemokine 5. The secretions from monocyte-derived dendritic cells stimulate the progression of
lung cancer cells, including the migration and invasion of cells. To the best of our knowledge, these secretions remain unknown, and require additional study. The present study identified that treatment with BaP-H1395-tumor-associated dendritic cell-
conditioned medium had the most marked effect on cell migration and invasion. This result may be associated with the female gender, stage 2
adenocarcinoma or mutation of the proto-oncogene B-Raf (BRAF), according to the cell line background.
Laricitrin, a dietary
flavonoid derivative present in grapes and red wine, suppresses certain factors and decreases the progression of
lung cancer cells that are promoted by BaP in the
lung cancer tumor microenvironment. The results of the present study suggest that prolonged exposure to BaP exacerbates
lung cancer, particularly in female
lung cancer patients with the BRAF mutation, but that
laricitrin may ameliorate this effect.