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The efficacy of amineptine in the treatment of depressive patients with irritable bowel syndrome.

Abstract
Patients with irritable bowel syndrome (IBS) often suffer from depression. In view of this, the effect of amineptine on the psychopathological condition of depressive patients with IBS was studied. Forty patients who satisfied the criteria for irritable bowel syndrome and had a Hamilton 24-item score above 15 were randomly assigned to receive either amineptine 200 mg/day or placebo in a double-blind clinical trial. Patients on amineptine were more improved at the end of the trial than patients on placebo (total Hamilton score). Amineptine was more effective on depressive mood, retardation, and cognitive dysfunction. Although these findings should be interpreted with caution because the baseline scores were higher in the amineptine than in the placebo group, they provide some evidence that amineptine may be a useful tool for the management of depressive patients with IBS.
AuthorsB Alevizos, G N Christodoulou, C Ioannidis, A Voulgari, A Mantidis, C Spiliadis
JournalClinical neuropharmacology (Clin Neuropharmacol) Vol. 12 Suppl 2 Pg. S66-76 ( 1989) ISSN: 0362-5664 [Print] United States
PMID2698273 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Dibenzocycloheptenes
  • amineptin
Topics
  • Adult
  • Antidepressive Agents, Tricyclic (adverse effects, therapeutic use)
  • Colonic Diseases, Functional (complications)
  • Depressive Disorder (complications, drug therapy)
  • Dibenzocycloheptenes (adverse effects, therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic

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