[Estimation of urinary excretion rate of guanidinoacetic acid in essential hypertension].

78 patients with essential hypertension (17 with borderline hypertension and 61 with hypertension) and 13 normal controls were examined to evaluate the relation between the urinary excretion rate of guanidinoacetic acid/creatinine (U-GAA/Cr), beta 2-microglobulin/creatinine (U-BMG/Cr), radio-sensitive microalbumin excretion rate/creatinine (U-AER/Cr), N-acetyl-D-glucosaminidase/creatinine (U-NAG/Cr) and renal function. There was no significant difference among these groups in creatinine clearance (Ccr), serum creatinine (Cr) or in U-BMG/Cr, U-NAG/Cr and U-AER/Cr. In hypertensive patients U-GAA/Cr was 49.2 +/- 16.7 mg/gCr, which was much lower than in controls (78.1 +/- 13.4) (p less than 0.001). The Ccr has a significant relation with U-GAA/Cr (r = 0.29, p less than 0.01) but not with U-AER/Cr, U-BMG/Cr nor U-NAG/Cr. In 44 patients, all of the above factors were investigated for 24 weeks during 4 kinds of anti-hypertensive treatment (10 with an angiotensin-converting enzyme inhibitor: A group, 11 with a beta-adrenergic blocker: B group, 12 with a Ca entry blocker: C group and 12 with diuretics: D group). In A and C group, U-GAA/Cr was elevated during therapeutic course. However, in B and D group it declined during treatment. These findings suggested that urinary excretion of GAA may be a more sensitive marker than AER, BMG or NAG in hypertension and angiotensin-converting enzyme inhibitor and Ca entry blocker can be useful in the treatment of patients with essential hypertension with renal damage.
AuthorsY Takano
JournalNihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 31 Issue 11 Pg. 1187-96 (Nov 1989) ISSN: 0385-2385 [Print] JAPAN
PMID2696798 (Publication Type: English Abstract, Journal Article)
Chemical References
  • beta 2-Microglobulin
  • Creatinine
  • Acetylglucosaminidase
  • glycocyamine
  • Glycine
  • Acetylglucosaminidase (urine)
  • Creatinine (urine)
  • Female
  • Glycine (analogs & derivatives, urine)
  • Humans
  • Hypertension (physiopathology, urine)
  • Kidney (physiopathology)
  • Male
  • Middle Aged
  • beta 2-Microglobulin (urine)

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