Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo).

Abstract

Four cases of histiocytic sarcoma in domestic ferrets (Mustela putorius furo) are described in the present study. Tumor samples obtained from the abdominal viscera, including the spleen, were submitted for histologic examination. Microscopically, poorly demarcated masses contained numerous round- to pleomorphic-shaped cells with coarsely vacuolated and eosinophilic cytoplasm. Bizarre, binucleated tumor cells and multinucleated giant tumor cells with low phagocytic activity were commonly observed. Immunohistochemically, tumor cells in all of the cases were positive for vimentin, human leukocyte antigen-DR, ionized calcium-binding adapter molecule-1, and lysozyme, but some of them lacked cluster of differentiation (CD)163 or CD208 expression. The survival time after surgical resection was 9 days to 5 months. Histiocytic sarcoma in the ferret is a rare, but highly aggressive, tumor commonly found in the spleen.

• Authors: Atigan Thongtharb, Kazuyuki Uchida, James K Chambers, Yasutsugu Miwa, Yousuke Murata, Hiroyuki Nakayama
• Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (J Vet Diagn Invest) Vol. 28 Issue 2 Pg. 165-70 (Mar 2016) ISSN: 1943-4936 [Electronic] United States
• PMID: 26965237 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 The Author(s).

Topics

• Animals
• Diagnosis, Differential
• Ferrets
• Histiocytic Sarcoma (diagnosis, veterinary)
• Immunohistochemistry (veterinary)