Severe anemia due to parvovirus B19 in a silver haired boy.

Abstract

Griscelli syndrome (GS) is a rare autosomal recessive immunodeficiency disorder in which the affected children present with characteristic silvery-white hairs. The hair microscopy of these children is characteristic and is helpful in differentiating GS from Chediak-Higashi syndrome which also presents with immunodeficiency and silver hairs. We report a 17-month-old boy with GS type 2 who presented with severe anemia. Bone marrow examination of the child suggested parvovirus B19 as the cause of severe anemia, which was later confirmed by DNA polymerase chain reaction.

• Authors: Nishant Verma, Archana Kumar, Rashmi Kushwaha
• Journal: Indian journal of pathology & microbiology (Indian J Pathol Microbiol) 2016 Jan-Mar Vol. 59 Issue 1 Pg. 110-2 ISSN: 0974-5130 [Electronic] India
• PMID: 26960654 (Publication Type: Case Reports, Journal Article)

Topics

• Anemia (etiology, pathology)
• Bone Marrow (pathology)
• Diagnostic Tests, Routine
• Humans
• Immunologic Deficiency Syndromes (complications)
• Infant
• Lymphohistiocytosis, Hemophagocytic (complications)
• Male
• Microscopy
• Parvoviridae Infections (complications, diagnosis, pathology, virology)
• Parvovirus B19, Human (isolation & purification)
• Piebaldism (complications)
• Polymerase Chain Reaction
• Primary Immunodeficiency Diseases