Abstract | WHAT IS KNOWN AND OBJECTIVE:
Neurofibromatosis is associated with overactivation of the RAS-MAPK pathway. MEK inhibitors have been shown to be an effective treatment modality in other malignancies. CASE SUMMARY: WHAT IS NEW AND CONCLUSION: This case highlights the therapeutic success of a MEK inhibitor in neurofibromatosis-associated glioblastoma. As a corollary, this should prompt evaluation of MEK inhibitors in tumours associated with neurofibromatosis. It remains to be elucidated if tumours with somatic NF1 mutations may also benefit from therapy targeting the RAS-MAPK pathway.
|
Authors | M Ameratunga, G McArthur, H Gan, L Cher |
Journal | Journal of clinical pharmacy and therapeutics
(J Clin Pharm Ther)
Vol. 41
Issue 3
Pg. 357-359
(Jun 2016)
ISSN: 1365-2710 [Electronic] England |
PMID | 26936308
(Publication Type: Case Reports)
|
Copyright | © 2016 John Wiley & Sons Ltd. |