Abstract |
In a multicenter, evaluator-blind, parallel group study of 244 patients with moderate to severe psoriasis, a once-daily application of a new formulation of beta-methasone dipropionate 0.05% cream, augmented formulation (AF), and a twice-daily application of fluocinonide 0.05% cream were compared, with respect to safety and efficacy. Results significantly favored betamethasone dipropionate AF over fluocinonide, as indicated by improvements in signs of erythema, induration, and scaling, as well as the physicians' and patients' global evaluations of response after 14 days of treatment. As a result of adverse experiences, treatment had to be discontinued in three patients on fluocinonide. No patient on betamethasone dipropionate AF had to discontinue treatment.
|
Authors | C N Ellis, H I Katz, I H Rex Jr, J S Shavin, E J Van Scott, D VanderPloeg |
Journal | Clinical therapeutics
(Clin Ther)
1989 Nov-Dec
Vol. 11
Issue 6
Pg. 768-74
ISSN: 0149-2918 [Print] United States |
PMID | 2692821
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Fluocinonide
- betamethasone-17,21-dipropionate
- Betamethasone
|
Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Betamethasone
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Double-Blind Method
- Female
- Fluocinonide
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Psoriasis
(drug therapy)
- Randomized Controlled Trials as Topic
|