Nephrotoxicity of contrast media in patients with diabetes mellitus. A comparative urographic and angiographic study with iohexol and metrizoate.

Abstract

A double-blind urographic and angiographic study was done with the ionic contrast medium meglumine metrizoate and the non-ionic iohexol in 90 patients with diabetes mellitus. Twenty patients were insulin dependent, and 70 non-insulin dependent diabetics. Diabetic patients with decreased as well as normal renal function prior to the examination sustained a reversible and small increase in the plasma creatinine level postexamination. The small increase caused by meglumine metrizoate was significantly higher than the increase caused by iohexol. There was also a significantly higher increase in plasma creatinine among the patients with diabetic nephropathy compared with those without nephropathy.

• Authors: A Billström, S O Hietala, F Lithner, J Merikanto, M Wirell, S Wirell
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) 1989 Sep-Oct Vol. 30 Issue 5 Pg. 509-15 ISSN: 0284-1851 [Print] England
• PMID: 2692666 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Iodobenzoates
• Iohexol
• Metrizoic Acid
• methylglucamine metrizoate

Topics

• Adult
• Aged
• Aged, 80 and over
• Angiography
• Clinical Trials as Topic
• Diabetes Mellitus, Type 1 (complications, diagnostic imaging)
• Diabetes Mellitus, Type 2 (complications, diagnostic imaging)
• Double-Blind Method
• Humans
• Iodobenzoates (adverse effects)
• Iohexol (adverse effects)
• Kidney (diagnostic imaging, drug effects)
• Kidney Diseases (chemically induced)
• Metrizoic Acid (adverse effects, analogs & derivatives)
• Middle Aged
• Prospective Studies
• Urography