Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery.

Abstract

OBJECTIVE:

The density of mast cells positive to tryptase (MCDPT) and tumor-associated macrophages (TAMs) were evaluated in a series of 87 patients with stage B and C colorectal cancer who had undergone radical surgery.

METHODS:

MCDPT, TAMs, microvascular density (MVD), endothelial area (EA) and CD8(+) tumor infiltrating lymphocytes (CD8(+) TILs) were evaluated in tumor tissue samples by immunohistochemistry and image analysis. Each of the above parameters was correlated with the others and with the main clinico-pathological features.

RESULTS:

A significant correlation between MCDPT, TAMs, MVD and EA was found by Pearson t-test analysis. With special references to the clinico-pathological features a minimal correlation using univariate analysis was found but it was not retained at multivariate analysis.

CONCLUSIONS:

Our data suggest that MCDPT and TAMs are linked in the tumor microenvironment and play a role in CRC angiogenesis in a synergistic manner. The assessment of the combination MCDPT and TAMs could be evaluated as a target of novel anti-angiogenic therapies in colorectal cancer patients.

• Authors: Michele Ammendola, Rosa Patruno, Rosario Sacco, Ilaria Marech, Giuseppe Sammarco, Valeria Zuccalà, Maria Luposella, Nicola Zizzo, Claudia Gadaleta, Mariangela Porcelli, Cosmo Damiano Gadaleta, Domenico Ribatti, Girolamo Ranieri
• Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 20 Issue 5 Pg. 533-40 ( 2016) ISSN: 1744-7631 [Electronic] England
• PMID: 26914851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tryptases

Topics

• Colorectal Neoplasms (metabolism, pathology, surgery)
• Female
• Humans
• Macrophages (metabolism)
• Male
• Mast Cells (metabolism)
• Middle Aged
• Neovascularization, Pathologic (metabolism)
• Tryptases (metabolism)