Comparison of one dose cefazolin versus one dose cefotetan for cesarean section prophylaxis.

Abstract

During one year, 646 women who delivered by cesarean section entered into a prospective randomized clinical trial to determine if a single intraoperative dose of cefazolin was as effective as cefotetan in the prevention of postoperative endomyometritis. Of 336 patients receiving 2 gm cefazolin intravenously at the time of clamping of the cord, endomyometritis developed in 30 (8.91%), and of 310 patients who received 2 gm cefotetan intravenously at the time of clamping of the cord, endomyometritis developed in 36 (11.6%). There was no statistically significant difference in the incidence of endomyometritis between the two groups (p = .269). We conclude that since the two drugs are equal in efficacy 2 gm of cefazolin is a cost effective method of prophylaxis for cesarean section.

• Authors: J R Probst, G I Benrubi, L Sanchez-Ramos, M Todd
• Journal: The Journal of the Florida Medical Association (J Fla Med Assoc) Vol. 76 Issue 12 Pg. 1027-9 (Dec 1989) ISSN: 0015-4148 [Print] United States
• PMID: 2689574 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cefotetan
• Cefazolin

Topics

• Adolescent
• Adult
• Bacterial Infections (prevention & control)
• Cefazolin (administration & dosage, therapeutic use)
• Cefotetan (administration & dosage, therapeutic use)
• Cesarean Section (adverse effects)
• Endometritis (prevention & control)
• Female
• Humans
• Intraoperative Care
• Prospective Studies
• Randomized Controlled Trials as Topic