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Dilevalol in severe hypertension. A multicenter trial of bolus intravenous dosing.

Abstract
Dilevalol, the R-R optical isomer of labetalol, a nonselective beta-antagonist with vasodilation from selective beta 2 agonism, was administered in sequential multiple bolus intravenous injections of 10 to 100 mg in total doses ranging from 35 to 585 mg (mean dose, 414 mg) to 101 patients with supine diastolic blood pressures above 120 mm Hg. Mean blood pressure was reduced from 200 (+/- 3)/129 (+/- 1) mm Hg to 149 (+/- 2)/101 (+/- 1) mm Hg, a mean reduction of 51/28 mm Hg. The therapeutic goal was established as a reduction in supine diastolic blood pressure to less than 100 mm Hg or a reduction of at least 30 mm Hg. This was achieved in 62 (61%) of 101 patients, with an additional 7 patients having a final supine diastolic blood pressure of 100 mm Hg. Treatment with dilevalol was less successful in black male patients than in the group at large. There was a tendency for older patients to respond better than younger patients. Prior recent treatment of patients with beta-adrenergic antagonists decreased the effectiveness of the drug. Significant orthostatic hypotension was not noted. Sixty-four patients were transferred to oral dilevalol treatment in combination with a diuretic, and blood pressure in this group averaged 160/100 mm Hg after 1 month of therapy. Dilevalol appears to be a safe and effective drug that can be used intravenously successfully in the majority of patients with severe hypertension and provides an alternative to therapy with other agents. It also is a useful agent for oral treatment of these patients after successful intravenous therapy.
AuthorsJ D Wallin, M E Cook, E Fletcher, J L Holtzman, N Winer, H Gavras, C E Grim, K B Ramanathan, D G Vidt, B F Johnson
JournalArchives of internal medicine (Arch Intern Med) Vol. 149 Issue 12 Pg. 2655-61 (Dec 1989) ISSN: 0003-9926 [Print] United States
PMID2688585 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Vasodilator Agents
  • Labetalol
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Infusions, Intravenous
  • Labetalol (adverse effects, therapeutic use)
  • Middle Aged
  • Multicenter Studies as Topic
  • Vasodilator Agents (therapeutic use)

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