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[Early Detection of Manganese Intoxication Based on Occupational History and T1-weighted MRI].

Abstract
Manganese regulates many enzymes and is essential for normal cell function. Chronic manganese intoxication has an insidious and progressive course terminating to atypical parkinsonism with little therapeutic efficacy. For subjects with chronic manganese exposure such as welders, manganese intoxication can be detected early based on the presence of hyperintensity in the globus pallidus on T(1)-weighted MRI and abnormally high urinary excretion of manganese with a chelating agent even in cases of normal serum/urine level of manganese.
AuthorsToshio Fukutake, Hajime Yano, Ryutaro Kushida, Yoshihide Sunada
JournalBrain and nerve = Shinkei kenkyu no shinpo (Brain Nerve) Vol. 68 Issue 2 Pg. 175-80 (Feb 2016) ISSN: 1881-6096 [Print] Japan
PMID26873238 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Manganese
Topics
  • Brain (pathology)
  • Early Diagnosis
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Manganese (pharmacology)
  • Manganese Poisoning (diagnosis, pathology)
  • Parkinsonian Disorders (diagnosis, pathology, physiopathology)

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