Atypical Presentations of Molar Pregnancy: Diagnostic Roles of Imaging, β-Human Chorionic Gonadotropin Measurement, and p57 Immunostaining.

Abstract

In modern practice , the diagnosis of molar pregnancy is made at an early gestational age. The opportunity to diagnose gestational trophoblastic disease (GTD) using sonography alone occurs less frequently. The classic appearance of a "snowstorm" in the endometrial cavity and bilateral theca lutein cysts still applies to the diagnosis of second-trimester GTD. The diagnosis of first-trimester GTD requires increased clinical suspicion. If the sonographic appearance of the pregnancy is atypical, GTD should be included in the differential diagnosis. Additional nonimaging criteria such as serial quantitative β-human chorionic gonadotropin levels, pathologic examination, and p57 (cyclin-dependent kinase inhibitor 1C protein) immunostaining can accurately confirm the diagnosis of GTD.

• Authors: Sara A Mohamed, Ayman Al-Hendy, Sharad Ghamande, Joanna Chaffin, Paul Browne
• Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine (J Ultrasound Med) Vol. 35 Issue 3 Pg. 643-9 (Mar 2016) ISSN: 1550-9613 [Electronic] England
• PMID: 26860483 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2016 by the American Institute of Ultrasound in Medicine.

Chemical References

• Biomarkers
• CDKN1C protein, human
• Chorionic Gonadotropin, beta Subunit, Human
• Cyclin-Dependent Kinase Inhibitor p57

Topics

• Adult
• Biomarkers (metabolism)
• Chorionic Gonadotropin, beta Subunit, Human (blood)
• Cyclin-Dependent Kinase Inhibitor p57 (metabolism)
• Female
• Humans
• Hydatidiform Mole (diagnosis, metabolism)
• Pregnancy
• Ultrasonography, Prenatal (methods)
• Young Adult