Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas.

Abstract

OBJECTIVE:

Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated with prognosis in several human neoplasms; however, its role in STS is unknown.

METHODS:

In the present study RKIP expression was assessed by immunohistochemistry in a series of 87 STSs, and its expression profile was associated with the patients' pathological parameters.

RESULTS:

We found that RKIP is expressed in the cytoplasm of the great majority of cases, and absent in only approximately 18% of cases (16/87). Importantly, we observed that loss of RKIP expression was associated with poor outcome, constituting an independent prognostic marker.

CONCLUSION:

This is the first study assessing RKIP expression levels in STS. We showed that loss of RKIP expression is present in a small subset of cases; however, its absence was associated with poor survival and may be a potential marker for STS prognosis.

• Authors: Olga Martinho, Marcelo Campos, Guilherme Ribeiro, Valter Penna, Emílio C Curcelli, Marcus V Olivieri, Sandra Morini, Cristovam Scapulatempo, Lucas F Abrahão-Machado, Rui M Reis
• Journal: Pathobiology : journal of immunopathology, molecular and cellular biology (Pathobiology) Vol. 83 Issue 1 Pg. 41-6 ( 2016) ISSN: 1423-0291 [Electronic] Switzerland
• PMID: 26859895 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 S. Karger AG, Basel.

Chemical References

• Biomarkers, Tumor
• PEBP1 protein, human
• Phosphatidylethanolamine Binding Protein

Topics

• Aged
• Biomarkers, Tumor
• Disease-Free Survival
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Phosphatidylethanolamine Binding Protein (genetics)
• Prognosis
• Sarcoma (diagnosis, genetics, pathology, ultrastructure)
• Survival Analysis