Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy.

Abstract

Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

• Authors: Keunsoo Jeong, Chi Soo Kang, Youngsun Kim, Yong-Deok Lee, Ick Chan Kwon, Sehoon Kim
• Journal: Cancer letters (Cancer Lett) Vol. 374 Issue 1 Pg. 31-43 (Apr 28 2016) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 26854717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Drug Carriers

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Drug Carriers (administration & dosage)
• Drug Delivery Systems (methods)
• Humans
• Nanoparticles (administration & dosage)
• Neoplasms (drug therapy)