| Abstract | Thirty-seven patients with poor prognosis, metastatic breast cancer were treated with 5-fluorouracil, vinblastine, and Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH) (FUVA) induction chemotherapy. All 26 patients (74%) with responsive or stable disease after induction chemotherapy received intensification with high-dose cyclophosphamide (120 mg/kg). Continued responders received additional FUVA as consolidation. The response rate to induction therapy was 54% (with complete response [CR] in 11%). With intensification, three patients (11%) showed improved response (partial response [PR] in one, PR to complete response [CR] in two); however, six patients (23%) progressed within 2 months of cyclophosphamide intensification, three within 1 month. The overall response rate to all three phases of the study was 69%, with CR in 23%. The median survival of all patients entered in this study was 15 months. For cyclophosphamide intensification, major toxicity consisted of leukopenia with fever requiring broad-spectrum antibiotics in 27%. The authors conclude that a single cycle of high-dose cyclophosphamide intensification in metastatic breast cancer does not result in significantly improved responses or prolonged survival. |
| Authors | G K Ellis, S Green, S Schulman, B L Tranum, R S Goldberg, R B Livingston
(Affiliation: Puget Sound Oncology, Consortium, Seattle, Washington.)
|
| Journal | Cancer
(Cancer)
Vol. 64
Issue 12
Pg. 2409-15
(Dec 15 1989)
ISSN: 0008-543X UNITED STATES |
| PMID | 2684382
(Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- FUVA protocol
- Doxorubicin
- Cyclophosphamide
- Fluorouracil
- Vinblastine
|
| Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Neoplasms
(secondary)
- Brain Neoplasms
(prevention & control)
- Breast Neoplasms
(drug therapy, mortality, pathology)
- Clinical Trials as Topic
- Cyclophosphamide
(administration & dosage, therapeutic use)
- Doxorubicin
(administration & dosage)
- Drug Administration Schedule
- Fluorouracil
(administration & dosage)
- Humans
- Neoplasm Recurrence, Local
- Prognosis
- Vinblastine
(administration & dosage)
|
