[Intravenous nimodipine in the treatment of cerebral vasospasm following subarachnoid hemorrhage caused by aneurysm rupture: a comparative multicenter study].
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| Abstract |
The efficacy of intravenous Nimodipine (used at the rate of 2 mg.h-1) was investigated in the treatment of delayed ischemic deterioration or angiographic vasospasm after subarachnoid haemorrhage caused by a ruptured aneurysm in a randomized, double-blind, placebo-controlled multicenter study. A total of 127 case reports was validated: 73 patients received Nimodipine, 54 received placebo. The two groups were comparable in demographic and clinical status data. Analysis of number of deaths and of patients with severe deficit related to vasospasm alone showed a significant statistical difference (Nimodipine = 19%; Placebo = 49%; p = 0.01). The risk of mortality connected with vasospasm was reduced by 82% in the treated group. Side effects were equally frequent in the two groups. The only difference noted was the increase in heart rate in group Nimodipine. The results of this study demonstrate the efficacy of intravenous Nimodipine in the treatment of consequences of cerebral vasospasm after a subarachnoid haemorrhage caused by a ruptured aneurysm.
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| Authors | J M Desbordes, P E Ades, M Guggiari |
| Journal | Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression (Agressologie) Vol. 30 Issue 7 Pg. 438-40 (Jun 1989) ISSN: 0002-1148 [Print] France |
| Vernacular Title | Nimodipine intraveineuse dans le traitement curatif du vasospasme cérébral secondaire aux hémorragies méningées par rupture anevrysmale: étude comparative multicentrique. |
| PMID | 2683824 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial) |
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