[Analysis of pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union].

Abstract

Pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union were analyzed. Almost all pancreatic proteases were already activated in the bile aspirated immediately after insertion of PTCD tube. However, inactive proteases gradually increased after continuation of drainage by PTCD. Pancreatic protease activities appeared again after clamping the PTCD tube. In vitro study of trypsin activities in the bile containing no initial trypsin activity, active type of trypsin did not appear throughout the experimental period. It is suggested that continuous reflux of pancreatic juice into the bile and certain incubation time are necessary for activation of pancreatic protease in bile of congenital choledochal cyst.

• Authors: T Shibata, T Hayakawa, T Kondo, M Kitagawa, Y Sakai, H Ono, S Kiriyama, Y Nimura, N Hayakawa, J Kamiya
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 86 Issue 7 Pg. 1513-8 (Jul 1989) ISSN: 0446-6586 [Print] Japan
• PMID: 2681892 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Peptide Hydrolases

Topics

• Adult
• Bile (enzymology)
• Bile Ducts (abnormalities)
• Choledochal Cyst (complications, enzymology)
• Humans
• Male
• Pancreas (enzymology)
• Pancreatic Ducts (abnormalities)
• Peptide Hydrolases (metabolism)