Sulconazole nitrate 1% cream in the treatment of chronic moccasin-type tinea pedis caused by Trichophyton rubrum.

Abstract

Sulconazole nitrate 1% cream applied twice daily was compared with its vehicle in the treatment of 229 patients with chronic moccasin-type tinea pedis confirmed by positive results of a potassium hydroxide preparation. At admission in this randomized, double-blind, parallel multicenter trial, 131 patients had positive dermatophyte cultures; Trichophyton rubrum was identified in 121 (92%). After 4 weeks of treatment, patients were examined and, if necessary, were treated for an additional 2 weeks. Sulconazole cream was significantly more effective than the vehicle in the treatment of chronic T. rubrum tinea pedis; 57% of patients were cured by sulconazole, compared with 13% cured with the vehicle. Relapse rates, assessed 2 weeks after the end of treatment, were significantly lower in patients treated with sulconazole than in those receiving vehicle (27% vs 71%). The 103 patients with moccasin-type tinea pedis whose cultures were not positive for T. rubrum achieved similar results.

• Authors: W A Akers, A Lane, Y Lynfield, J Greenberg, J Hall, C Mangan, A Tinker
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 21 Issue 4 Pt 1 Pg. 686-9 (Oct 1989) ISSN: 0190-9622 [Print] United States
• PMID: 2681281 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Imidazoles
• Pharmaceutical Vehicles
• sulconazole

Topics

• Adolescent
• Adult
• Aged
• Antifungal Agents (administration & dosage)
• Child
• Chronic Disease
• Double-Blind Method
• Female
• Humans
• Imidazoles (administration & dosage)
• Male
• Middle Aged
• Pharmaceutical Vehicles
• Randomized Controlled Trials as Topic
• Recurrence
• Tinea Pedis (drug therapy)
• Trichophyton