A double-blind comparison of the efficacy of betamethasone dipropionate cream twice daily versus once daily in the treatment of steroid responsive dermatoses.

Abstract

A total of 97 out-patients with steroid responsive dermatoses (63 eczema, 34 psoriasis) were recruited from two centres. They were randomly allocated in a double-blind manner to receive either betamethasone dipropionate cream twice daily or betamethasone dipropionate cream in the morning and base cream in the evening. The treatment period was 3 weeks. Eighty-five patients completed the study. There were no statistical differences between once daily application and twice daily for all of the parameters studied in both the eczema and psoriasis patients. Analysis of the diary card records, however, showed that symptomatic relief occurred more quickly in eczema patients receiving twice daily application of betamethasone dipropionate cream (P = 0.03). The use of betamethasone dipropionate cream once daily in conjunction with an emollient provides a regime which is as effective as a twice daily application of betamethasone dipropionate.

• Authors: J S English, C B Bunker, K Ruthven, P M Dowd, M W Greaves
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 14 Issue 1 Pg. 32-4 (Jan 1989) ISSN: 0307-6938 [Print] England
• PMID: 2680178 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids
• betamethasone-17,21-dipropionate
• Betamethasone

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (administration & dosage)
• Betamethasone (administration & dosage, analogs & derivatives)
• Clinical Trials as Topic
• Double-Blind Method
• Eczema (drug therapy)
• Glucocorticoids
• Humans
• Middle Aged
• Psoriasis (drug therapy)