Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency.

Abstract

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD.

• Authors: Reza Yazdani, Maryam Fatholahi, Mazdak Ganjalikhani-Hakemi, Hassan Abolhassani, Gholamreza Azizi, Kabir Magaji Hamid, Nima Rezaei, Asghar Aghamohammadi
• Journal: Molecular immunology (Mol Immunol) Vol. 71 Pg. 1-9 (Mar 2016) ISSN: 1872-9142 [Electronic] England
• PMID: 26795881 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Topics

• Apoptosis (immunology)
• B-Lymphocyte Subsets (immunology, pathology)
• Common Variable Immunodeficiency (immunology, pathology)
• Humans
• IgA Deficiency (immunology, pathology)
• T-Lymphocyte Subsets (immunology, pathology)