[Prevention of stomatitis induced by anti-cancer drugs].

Abstract

A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.

• Authors: H Dozono, K Nakamura, T Motoya, S Nakamura, R Shinmura, K Miwa, M Ishibashi, Y Nagata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 10 Pg. 3449-51 (Oct 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2679397 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Mouthwashes
• Dactinomycin
• Vincristine
• Allopurinol
• Cyclophosphamide
• Fluorouracil

Topics

• Allopurinol (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Clinical Trials as Topic
• Cyclophosphamide (administration & dosage, adverse effects)
• Dactinomycin (administration & dosage, adverse effects)
• Female
• Fluorouracil (administration & dosage, adverse effects)
• Genital Neoplasms, Female (drug therapy)
• Humans
• Mouth Mucosa
• Mouthwashes
• Random Allocation
• Stomatitis (chemically induced, prevention & control)
• Vincristine (administration & dosage, adverse effects)