Mature Testicular Teratoma with Positive Estrogen Receptor Beta Expression in a Transgendered Individual on Cross-Sex Hormonal Therapy: A Case Report.

Abstract

Estrogen exposure has been linked to a risk of testicular germ cell cancers, although predominantly in animal studies. In the human testis, estrogen receptor beta (ER-β) mediates the physiological action of estrogen. We describe a case of a 30-year-old transgender woman (male-to-female [MtF]) with gender dysphoria who developed a mature testicular teratoma with positive estrogen receptor beta expression while receiving cross-sex hormonal therapy with estradiol and progesterone. Although the presence of hormone receptors does not always imply that hormones have played a role in the development of the tumor, a contribution of exposure to exogenous estrogen in this case cannot be ruled out.

• Authors: Yoshitomo Kobori, Keisuke Suzuki, Toshiyuki Iwahata, Takeshi Shin, Ryo Sato, Kojiro Nishio, Hiroshi Yagi, Gaku Arai, Shigehiro Soh, Hiroshi Okada
• Journal: LGBT health (LGBT Health) Vol. 2 Issue 1 Pg. 81-3 (Mar 2015) ISSN: 2325-8306 [Electronic] United States
• PMID: 26790022 (Publication Type: Case Reports, Journal Article)

Chemical References

• Estrogen Receptor beta
• Estrogens
• Progesterone
• Estradiol

Topics

• Adult
• Estradiol (therapeutic use)
• Estrogen Receptor beta (immunology)
• Estrogens (metabolism)
• Female
• Humans
• Male
• Neoplasms, Germ Cell and Embryonal (etiology)
• Progesterone (therapeutic use)
• Teratoma (surgery)
• Testicular Neoplasms (etiology, surgery)
• Testis (metabolism, surgery)
• Transgender Persons