[A double-blind comparative study of intracoronary administration of GE-0943 and urokinase: multicenter study].

Abstract

Coronary thrombolysis with plasminogen proactivator, GE-0943, was undertaken in patients with acute myocardial infarction and compared with urokinase. Fifty patients were given 6000 units of GE-0943 intracoronary and the totally occluded infarct-related arteries were recanalized in 92.0%. Fifty-four patients who were given 3000 units of GE-0943 intracoronary demonstrated a recanalization rate of 68.2%, while intracoronary administration of urokinase in 54 patients showed a recanalization rate of 70.4%. There was only one patient with hemorrhagic complication among GE-0943 3000-units group, none among GE-0943 6000-units group, and 5 among urokinase group. Thus, intracoronary administration of GE-0943 is very effective and safe with a dose up to 6000 units.

• Authors: H Kambara, C Kawai, N Kajiwara, K Kammatsuse, H Nitani, S Sasayama, K Kodama, H Sato, M Nobuyoshi, M Nakashima
• Journal: Kokyu to junkan. Respiration & circulation (Kokyu To Junkan) Vol. 37 Issue 7 Pg. 749-56 (Jul 1989) ISSN: 0452-3458 [Print] Japan
• PMID: 2678331 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Enzyme Precursors
• plasminogen proactivator
• Plasminogen Activators
• Urokinase-Type Plasminogen Activator

Topics

• Adult
• Aged
• Aged, 80 and over
• Clinical Trials as Topic
• Double-Blind Method
• Enzyme Precursors (administration & dosage, therapeutic use)
• Humans
• Middle Aged
• Multicenter Studies as Topic
• Myocardial Infarction (drug therapy)
• Plasminogen Activators (administration & dosage, therapeutic use)
• Urokinase-Type Plasminogen Activator (administration & dosage, therapeutic use)