[The PM-Scl (polymyositis-scleroderma) autoantibody and its nucleolar fluorescence pattern].

Abstract

By indirect immunofluorescence studies of antinuclear antibodies on hamster liver imprints as a substrate performed to determine the nuclear staining pattern of sera from patients with connective tissue diseases 10 sera showed a distinct homogeneous nucleolar staining pattern associated with weaker speckled or homogeneous nucleoplasmic fluorescence. In all 10 cases the antibodies revealed the PM-Scl specificity in immunodiffusion. Clinically 9 patients had an acrosclerosis, in 56% overlapped with symptoms of polymyositis. Only one patient had a diffuse scleroderma. The homogeneous nucleolar immunofluorescence pattern of PM-Scl should be distinguished from mixed nucleolar and diffuse reticular nucleoplasmic pattern of Scl-70.

• Authors: G Kühn, M Jarzabek-Chorzelska, M Blaszczyk, Z Kolacinska-Strasz, T P Chorzelski, S Jablonska
• Journal: Dermatologische Monatschrift (Dermatol Monatsschr) Vol. 175 Issue 8 Pg. 479-83 ( 1989) ISSN: 0011-9083 [Print] Germany
• Vernacular Title: Der PM-Scl- (Polymyositis-Sklerodermie-) Autoantikörper und sein nukleoläres Fluoreszenzmuster.
• PMID: 2676628 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antinuclear
• Nuclear Proteins
• Scl 70 antigen, human
• DNA Topoisomerases, Type I

Topics

• Antibodies, Antinuclear (analysis)
• Cell Nucleolus (ultrastructure)
• DNA Topoisomerases, Type I
• Fluorescent Antibody Technique
• Humans
• Myositis (pathology)
• Nuclear Proteins (immunology)
• Scleroderma, Systemic (pathology)