| Abstract | By indirect immunofluorescence studies of antinuclear antibodies on hamster liver imprints as a substrate performed to determine the nuclear staining pattern of sera from patients with connective tissue diseases 10 sera showed a distinct homogeneous nucleolar staining pattern associated with weaker speckled or homogeneous nucleoplasmic fluorescence. In all 10 cases the antibodies revealed the PM-Scl specificity in immunodiffusion. Clinically 9 patients had an acrosclerosis, in 56% overlapped with symptoms of polymyositis. Only one patient had a diffuse scleroderma. The homogeneous nucleolar immunofluorescence pattern of PM-Scl should be distinguished from mixed nucleolar and diffuse reticular nucleoplasmic pattern of Scl-70. |
| Authors | G Kühn, M Jarzabek-Chorzelska, M Blaszczyk, Z Kolacinska-Strasz, T P Chorzelski, S Jablonska |
| Journal | Dermatologische Monatschrift
(Dermatol Monatsschr)
Vol. 175
Issue 8
Pg. 479-83
( 1989)
ISSN: 0011-9083 GERMANY, EAST |
| Vernacular Title | Der PM-Scl- (Polymyositis-Sklerodermie-) Autoantikörper und sein nukleoläres Fluoreszenzmuster. |
| PMID | 2676628
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Antibodies, Antinuclear
- Nuclear Proteins
- Scl 70 antigen, human
|
| Topics |
- Antibodies, Antinuclear
(analysis)
- Cell Nucleolus
(ultrastructure)
- Fluorescent Antibody Technique
- Humans
- Myositis
(pathology)
- Nuclear Proteins
(immunology)
- Scleroderma, Systemic
(pathology)
|
