Age-related differences in the coordination disturbance and anticonvulsant effect of oxazepam in mice.

Abstract

The effects of oxazepam on coordination and maximal seizure were compared between young (6-month-old) and old (24-month-old) BDF1 mice by using a rotorod test and a pentylenetetrazole (PTZ)-induced seizure test, respectively. The apparent sensitivity to oxazepam's anticonvulsant effect, as examined by its effect on PTZ-induced maximal seizure, was increased in old animals of both sexes in comparison to young ones. The effect of oxazepam on coordination was also significantly greater in old male mice as compared with the young. The results of the present study, together with our past observations on other anticonvulsants such as phenytoin and phenobarbital, strongly suggest that the anticonvulsant effect, as well as the effect on coordination, in mice generally increases with age.

• Authors: K Kitani, U Klotz, S Kanai, Y Sato, M Ohta, M Nokubo
• Journal: Archives of gerontology and geriatrics (Arch Gerontol Geriatr) Vol. 9 Issue 1 Pg. 31-43 (Jul 1989) ISSN: 0167-4943 [Print] Netherlands
• PMID: 2675790 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anticonvulsants
• Oxazepam

Topics

• Age Factors
• Animals
• Anticonvulsants (pharmacology)
• Dose-Response Relationship, Drug
• Mice
• Mice, Inbred Strains
• Oxazepam (adverse effects, pharmacology)
• Psychomotor Performance (drug effects)