Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets--"Sand Out and Gold Stays".
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| Abstract |
To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: (1) Histone enzymes are differentially expressed in cardiovascular, immune, and other tissues; (2) our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, and histone methylation/demethylation are in the highest varieties; and (3) histone enzymes are more downregulated than upregulated in metabolic diseases and regulatory T cell (Treg) polarization/ differentiation, but not in tumors. These results have demonstrated a new working model of "Sand out and Gold stays," where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.
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| Authors | Ying Shao, Valeria Chernaya, Candice Johnson, William Y Yang, Ramon Cueto, Xiaojin Sha, Yi Zhang, Xuebin Qin, Jianxin Sun, Eric T Choi, Hong Wang, Xiao-feng Yang |
| Journal | Journal of cardiovascular translational research (J Cardiovasc Transl Res) Vol. 9 Issue 1 Pg. 49-66 (Feb 2016) ISSN: 1937-5395 [Electronic] United States |
| PMID | 26746407 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural) |
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