Synthesis of cis-bicyclo[4.3.0]non-2-ene derivatives. The potent homoisocarbacyclin analogs.

Abstract

Synthesis of homoisocarbacyclin has been achieved efficiently by a general strategy with stereo- and regiochemical control. One of homoisocarbacyclin derivatives, 3-oxa homoisocarbacyclin analog (4), was shown to be potently active in inhibiting gastric ulcer. Another analog, conjugated diene derivative (5), was found to have a biological profile similar to prostacyclin.

• Authors: M Shibasaki, A Takahashi, T Aoki, H Sato, S Narita
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 37 Issue 6 Pg. 1647-9 (Jun 1989) ISSN: 0009-2363 [Print] Japan
• PMID: 2673560 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• bicyclo(4.3.0)non-2-ene homoisocarbacyclin
• 3-oxahomoisocarbacyclin
• homoisocarbacyclin
• Epoprostenol

Topics

• Anti-Ulcer Agents (chemical synthesis)
• Chemical Phenomena
• Chemistry
• Epoprostenol (chemical synthesis, pharmacology)