The Effectiveness of Porcine Dermal Collagen (Permacol(®)) on Wound Healing in the Rat Model.

Abstract

Porcine acellular dermal collagen (PDC), which is a biological material derived from processing porcine dermis, has already been used for urologic, gynecologic, plastic, and general surgery procedures up to now. The aim of this study is to investigate the effectiveness of PDC on wound healing as a dermal substitute in the rat model. Twenty Wistar albino rats were divided into two groups. Standard full-thickness skin defects were created on the back of the rats. In the control group (Group 1), the dressings moisturized with saline were changed daily. In the study group (Group 2), porcine dermal collagen was implanted onto each wound and fixed with 4-0 polypropylene sutures. Contraction percentages of wound areas were calculated on the third, seventh, tenth, and fourteenth days by using the planimetric program. On fourteenth day, the wound areas were excised for histopathological examination, inflammatory scoring, and evaluation of collagen deposition. The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio, and wound contraction rates. Porcine dermal collagen may be used effectively and safely on full-thickness wounds as a current dermal substitute.

• Authors: Murat Kalin, Serdar Kuru, Kemal Kismet, Aziz Mutlu Barlas, Yusuf Akif Akgun, Hesna Muzeyyen Astarci, Huseyin Ustun, Ertugrul Ertas
• Journal: The Indian journal of surgery (Indian J Surg) Vol. 77 Issue Suppl 2 Pg. 407-11 (Dec 2015) ISSN: 0972-2068 [Print] India
• PMID: 26730035 (Publication Type: Journal Article)