Abstract | UNLABELLED: The first drug of sublingual immunotherapy (SLIT) for Japanese Cedar pollinosis (JCP) was purchased in 2014. PURPOSE: The purpose of this study is to clear the clinical efficacy of SLIT by comparing with other therapies, such as subcutaneous immunotherapy (SCIT), or other pharmacotherapy. METHODS: We started SLIT at our clinic in October-December, 2014. We compared the clinical efficacy of 191 SLIT with 48 SCIT, 191 primary pharmacotherapy that started therapies before pollen dispersal, 141 pharmacotherapy that started therapies after pollen disposal, or 169 non-treatment in the first follow-up year. The clinical efficacy was evaluated with quality of life (QOL) scores by Japanese rhino-conjunctivitis QOL questionnaire (JRQLQ No1), symptoms of nose and eye by visual analog scale (VAS), symptom scores and combined symptom-medication scores (SMS). RESULTS: Mild adverse events (AEs) were observed in many cases, but no patient was discontinued by AEs in SLIT patients. Five cases by unknown reasons and 3 cases by inevitable reasons were dropped out before pollen. Adherence of SLIT was 89±12%. SCIT was better than SLIT in most assessments, but not significant. Both SCIT and SLIT were significantly better than other pharmacotherapy. Patients, whose symptom scores of nose and eye were 0 or 1 point without any rescue drugs, accounted for 16.8% of total SLIT in the first follow-up year. CONCLUSION: SCIT was slightly better than SLIT in reducing symptoms and SMS of JCP, and in improving QOL. However, the differences were not significant. SLIT was significantly effective than other pharmacotherapies.
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Authors | Atsushi Yuta, Yukiko Ogawa, Yusuke Suzuki, Masahiko Arikata, Hideaki Kozaki, Takeshi Shimizu, Nobuo Ohta |
Journal | Arerugi = [Allergy]
(Arerugi)
Vol. 64
Issue 10
Pg. 1323-33
(Dec 2015)
ISSN: 0021-4884 [Print] Japan |
PMID | 26727137
(Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Administration, Sublingual
- Adult
- Cryptomeria
- Female
- Humans
- Immunotherapy
(methods)
- Male
- Quality of Life
- Rhinitis, Allergic, Seasonal
(drug therapy, therapy)
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