Association of GSTs gene polymorphisms with treatment outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy.

Abstract	We evaluated the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the clinical response to chemotherapy and treatment outcome of NSCLC. Between October 2009 and October 2012, a total of 282 patients with advanced NSCLC were enrolled into our study, and they were followed up until October 2014. The genotypes of GSTM1, GSTT1, and GSTP1 IIe105Val were performed by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). By logistic regression analysis, our study found that the Val/Val genotype of GSTP1 IIe105Val was associated with more CR+PR response to chemotherapy when compared with the IIe/IIe genotype, and the OR (95% CI) was 2.18 (1.16-4.12). By multivariate Cox proportional hazards regression analysis, we found the Val/Val genotype of GSTP1 was correlated with lower risk of death in advanced NSCLC (HR, 0.48; 95% CI, 0.25-0.93). However, no association was found between GSTT1 and GSTM1 polymorphisms and response to chemotherapy and overall survival of advanced NSCLC. Moreover, the IIe/Val + Val/Val genotypes of GSTP1 were associated with lower risk of death in never smokers, and the adjusted HR (95% CI) was 0.34 (0.12-0.93). In conclusion, we found that the GSTP1 polymorphism was correlated with better response to chemotherapy and lower risk of death in advanced NSCLC patients.
Authors	Gun Wu, Bin Jiang, Xiaoqin Liu, Yi Shen, Shujuan Yang
Journal	International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 10 Pg. 13346-52 ( 2015) ISSN: 1936-2625 [Electronic] United States
PMID	26722539 (Publication Type: Journal Article)
Chemical References	Antineoplastic Agents Glutathione Transferase Cisplatin
Topics	Aged Antineoplastic Agents (therapeutic use) Carcinoma, Non-Small-Cell Lung (drug therapy, genetics, mortality, pathology) Case-Control Studies Cisplatin (therapeutic use) Female Gene Frequency Genotype Glutathione Transferase (genetics) Humans Lung Neoplasms (drug therapy, genetics, mortality, pathology) Male Middle Aged Pharmacogenetics Polymorphism, Single Nucleotide Prognosis Survival Rate Treatment Outcome

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