Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance.

Abstract

Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). We investigated the immunohistochemical expression of five SSTR subtypes (SSTR1-SSTR5) in tumor tissue sections from 60 patients with diagnosis of meningioma who underwent surgical resection and relating it to patient age and sex, tumor histology, location, regrowth/recurrence and follow-up. Mean (SD) patients age was 53.18 (12.6) years and 44 were women (73.3%). According to the WHO histological grading criteria, 47 (78.3%) meningiomas were grade I, 11 (18.3%) were grade II, and 2 (3.3%) were grade III. All five SSTRs were expressed in our sample, at frequencies ranging from 61.6 to 100%, with a predominance of SSTR2. SSTR5 was more frequently expressed in tumors benign than in tumors malignant (P<0.013). Recurrence-free survival rate at 2 years was 75.2%. There were no significant differences in SSTR expression regarding age, sex, tumor location and regrowth/recurrence. SSTR expression was detected at a significant frequency in this series. SSTR5 showed higher expression in tumors benign supporting the use of these SSTRs in diagnostic of meningiomas and their influence in process of tumorigenesis in meningiomas recurrence.

• Authors: Camila Batista de Oliveira Silva, Bárbara Roberta Ongaratti, Geraldine Trott, Taiana Haag, Nelson Pires Ferreira, Carolina Garcia Soares Leães, Julia Fernanda Semmelmann Pereira-Lima, Miriam da Costa Oliveira
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 10 Pg. 13185-92 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26722517 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Receptors, Somatostatin

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Meningeal Neoplasms (metabolism, mortality, pathology)
• Meningioma (metabolism, mortality, pathology)
• Middle Aged
• Prognosis
• Receptors, Somatostatin (analysis, biosynthesis)