Substances with antineoplastic activity. XCVI. Some pharmacological properties and therapeutic synergism of 6-purinyl-N-(2-chloroethyl)thiocarbamate with cytosine arabinoside.

Abstract

The cancerostatic effect of 6-purinyl-N-(2-chloroethyl)thiocarbamate (Cloturin VUFB, VUFB-15686) was studied in detail in mice and rats bearing transplantable tumors. The cytotoxic activities were measured by determining the incorporation rate of 5-iodo-2'-deoxy[6-3H]uridine and uniformly labeled [U-14C]amino acid mixture into trichloroacetic acid-insoluble fraction of Yoshida ascites reticulosarcoma cells during a short-term incubation with the drug. From the results obtained it follows that the new substance is therapeutically more effective in comparison with 6-mercaptopurine (NSC-755). A therapeutic synergism of Cloturin with cytosine arabinoside (NSC-63978) was observed.

• Authors: M Mĕlka, J Krepelka, M Miko, S Pokorná, I Kejhová, R Reichlová, M Beitová, J Grimová, A Kargerová, J Sedivá
• Journal: Neoplasma (Neoplasma) Vol. 36 Issue 4 Pg. 419-25 ( 1989) ISSN: 0028-2685 [Print] Slovakia
• PMID: 2671756 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Mustard Compounds
• RNA, Neoplasm
• Cytarabine
• Cloturin
• Mercaptopurine

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cytarabine (administration & dosage, therapeutic use)
• DNA, Neoplasm (biosynthesis, drug effects)
• Female
• Lymphoma, Large B-Cell, Diffuse (drug therapy, metabolism)
• Melanoma, Experimental (drug therapy)
• Mercaptopurine (administration & dosage, analogs & derivatives, therapeutic use)
• Mice
• Mice, Inbred C57BL
• Mustard Compounds (administration & dosage, therapeutic use)
• Neoplasms, Experimental (drug therapy)
• RNA, Neoplasm (biosynthesis)
• Rats
• Rats, Inbred Strains