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[Clinical Analysis on Treatment of Chronic Myelomonocytic Leukemia with Allogeneic Hematopoietic Stem Cell Transplantation].

AbstractOBJECTIVE:
To analyze retrospectively the therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelomonocytic leukemia (CMML).
METHODS:
The engraftment, graft versus host disease (GVHD), infection, relapse, and survival of 13 CMML patients received allo-HSCT were observed. The clinical outcome of allo-HSCT for CMML was analyzed.
RESULTS:
Thirteen (10 males and 3 females) CMML patients with a median age of 38 years old received allo-HSCT including 4 from HLA-matched unrelated donors, 6 from HLA-matched sibling donors and 3 from haploidentical related donors. All 13 patients achieved engraftment, and the median time of neutrophil engraftment and platelet engraftment were 12 (11-18) days and 15 (10-55) days respectively, acute GVHD occurred in 8 patients. After the median follow-up of 13 (6-29) months, the overall survival, disease free survival and relapse were 53.8%, 53.8%, 7.7%, respectively.
CONCLUSION:
Allo-HSCT can improve the survival of patients with CMML, and is a effective method for treatment of CMML.
AuthorsTong Wang, Wei-Yang Li, Xiao-Fei Qi, Ri Zhang, Zhen-Ming Jing, Hui-Ying Qiu, Yue Han, Xiao Ma, Cheng-Cheng Fu, Xiao-Wen Tang, Su-Ning Chen, Ai-Ning Sun, De-Pei Wu
JournalZhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 23 Issue 6 Pg. 1667-72 (Dec 2015) ISSN: 1009-2137 [Print] China
PMID26708891 (Publication Type: Journal Article)
Topics
  • Adult
  • Disease-Free Survival
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Leukemia, Myelomonocytic, Chronic
  • Male
  • Retrospective Studies
  • Siblings
  • Tissue Donors
  • Transplantation, Homologous

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