HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Relationship of plasma matrix metalloproteinase-9 and hematoma expansion in acute hypertensive cerebral hemorrhage.

Abstract
In the present study, we aimed to investigate the relationship of plasma matrix metalloproteinase-9 (MMP-9) and hematoma expansion (HE) in acute hypertensive cerebral hemorrhage (AHCH) (HE-in-AHCH). Patients with hypertensive cerebral hemorrhage, confirmed by head computed tomography (CT) within 12 h of onset, were prospectively collected. Venous blood was sampled within 4 h of the confirmation to determine the serum MMP-9 concentration. The blood pressure and National Institute of Health Stroke Score of the patients were recorded on hospital admission. CT re-scanning was performed within 42-54 h of the first head CT examination or immediately after worsening of the patients' consciousness disorder. The relationship between MMP-9 level and HE was analyzed. A total of 186 patients were included. Of these patients, 41 had HE (22.0%). Multivariate logistic regression analysis showed that, in addition to the short interval between onset and the first CT examination, and the irregularity of hematoma shape, increasing MMP-9 level was an independent risk factor for HE-in-AHCH (OR value = 15.65, 95% CI: 5.30-46.15). Moreover, increasing plasma MMP-9 level was identified as an independent risk factor in patients with HE-in-AHCH.
AuthorsQingwei Yang, Xiaorong Zhuang, Feng Peng, Weihong Zheng
JournalThe International journal of neuroscience (Int J Neurosci) Vol. 126 Issue 3 Pg. 213-8 ( 2016) ISSN: 1563-5279 [Electronic] England
PMID26708160 (Publication Type: Journal Article)
Chemical References
  • Matrix Metalloproteinase 9
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain (pathology)
  • Cerebral Hemorrhage (blood, complications, pathology)
  • Female
  • Hematoma (blood, complications, pathology)
  • Humans
  • Intracranial Hemorrhage, Hypertensive (blood, complications, pathology)
  • Male
  • Matrix Metalloproteinase 9 (blood)
  • Middle Aged
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: