Abstract | BACKGROUND: METHODS: Patients with advanced NSCLC who were treated with icotinib hydrochloride in Beijing Chest Hospital were retrospective analyzed from March 2009 to December 2014. RESULTS: The clinical data of 124 patients (99 with EGFR mutation and 25 with wild type) with advanced NSCLC were enrolled in this study. The patients' overall objective response rate (ORR) was 51.6 % and the disease control rate (DCR) was 79.8%; The patients with EGFR mutation, ORR was 63.6%, DCR was 93.9%. The ORR was 4.0% and the DCR was 24.0% in the wild-type patients. Median progression-free survival (PFS) with icotinib treatment in EGFR mutation patients was 10.5 months and 1.0 month in wild-type patients. The major adverse events were mild skin rash (30.6%) and diarrhea (16.1%). CONCLUSIONS: Monotherapy with icotinib hydrochloride is effective and tolerable for the advanced NSCLC EGFR mutation patients.
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Authors | Xi Li, Na Qin, Jinghui Wang, Xinjie Yang, Xinyong Zhang, Jialin Lv, Yuhua Wu, Hui Zhang, Jingying Nong, Quan Zhang, Shucai Zhang |
Journal | Zhongguo fei ai za zhi = Chinese journal of lung cancer
(Zhongguo Fei Ai Za Zhi)
Vol. 18
Issue 12
Pg. 734-9
(Dec 2015)
ISSN: 1999-6187 [Electronic] China |
PMID | 26706949
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Crown Ethers
- Quinazolines
- icotinib
- EGFR protein, human
- ErbB Receptors
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, genetics, metabolism, mortality)
- China
- Crown Ethers
(administration & dosage)
- Disease-Free Survival
- ErbB Receptors
(genetics, metabolism)
- Female
- Humans
- Lung Neoplasms
(drug therapy, genetics, metabolism, mortality)
- Male
- Middle Aged
- Mutation
- Quinazolines
(administration & dosage)
- Retrospective Studies
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