Abstract | BACKGROUND: METHODS: RESULTS: Apoptosis, which was induced by all HDAC inhibitors, was particularly significant in HNHA-treated cells, where noticeable B-cell lymphoma-2 (Bcl-2) suppression and caspase activation were observed both in vitro and in vivo. HNHA increased Ca(2+) release from the ER to the cytoplasm. ER stress-dependent apoptosis was induced by HNHA, suggesting that it induced caspase-dependent apoptotic cell death in PTC and ATC. PTC and ATC xenograft studies demonstrated that the antitumor and pro-apoptotic effects of HNHA were greater than those of the established HDAC inhibitors. These HNHA activities reflected its induction of caspase-dependent and ER stress-dependent apoptosis on thyroid cancer cells. CONCLUSIONS: The present study indicated that HNHA possibly provide a new clinical approach to thyroid cancers, including ATC.
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Authors | Seok-Mo Kim, Ki-Cheong Park, Jeong-Yong Jeon, Bup-Woo Kim, Hyeung-Kyoo Kim, Ho-Jin Chang, Seung-Hoon Choi, Cheong-Soo Park, Hang-Seok Chang |
Journal | BMC cancer
(BMC Cancer)
Vol. 15
Pg. 1003
(Dec 23 2015)
ISSN: 1471-2407 [Electronic] England |
PMID | 26698299
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histone Deacetylase Inhibitors
- Hydroxamic Acids
- N-hydroxy-7-(2-naphthylthio)heptanamide
- Naphthalenes
- Proto-Oncogene Proteins c-bcl-2
- Caspases
- Calcium
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Topics |
- Apoptosis
(drug effects)
- Calcium
(metabolism)
- Caspases
(metabolism)
- Cell Line, Tumor
- Endoplasmic Reticulum
(metabolism)
- Histone Deacetylase Inhibitors
(pharmacology)
- Humans
- Hydroxamic Acids
(pharmacology)
- Immunohistochemistry
- Naphthalenes
(pharmacology)
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- Thyroid Neoplasms
(drug therapy, metabolism)
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