Abstract | BACKGROUND:
Ameloblastoma (AM) is a benign odontogenic neoplasm characterized by local invasiveness and recurrence. We compared the immunohistochemical expression of matrix metalloproteinases in different clinical types of AM as well as in normal odontogenic tissue. METHODS: RESULTS: The expressions of MMP-1 and MMP-2 were very high in the cytoplasm of cells throughout the entire epithelium and in fibroblasts from the adjacent connective tissue. MMP-9 expression was observed in the same location although with weaker staining. The Kruskal-Wallis test showed statistically significant differences in the epithelial expressions of MMP-1 and MMP-2; there was lower expression among solid AMs when compared with unicystic AM and PF. Compared to both types of AM, higher stromal expression of MMP-9 was found in PF. CONCLUSION: MMP-1, MMP-2 and MMP-9 seem to be associated with AM tumour behaviour as well as physiological tissue remodelling within PF.
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Authors | Kamile Leonardi Dutra, Mabel Mariela Rodríguez Cordeiro, Daniella Serafin Couto Vieira, Elena Riet Correa Rivero |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 45
Issue 8
Pg. 586-90
(Sep 2016)
ISSN: 1600-0714 [Electronic] Denmark |
PMID | 26694521
(Publication Type: Journal Article)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Matrix Metalloproteinases
- MMP2 protein, human
- Matrix Metalloproteinase 2
- MMP9 protein, human
- Matrix Metalloproteinase 9
- MMP1 protein, human
- Matrix Metalloproteinase 1
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Topics |
- Ameloblastoma
(enzymology, metabolism, pathology)
- Connective Tissue
(enzymology, pathology)
- Dental Sac
(enzymology, metabolism, pathology)
- Epithelium
(enzymology, metabolism, pathology)
- Fibroblasts
(enzymology, metabolism, pathology)
- Humans
- Immunohistochemistry
- Jaw Neoplasms
(enzymology, metabolism, pathology)
- Matrix Metalloproteinase 1
(biosynthesis)
- Matrix Metalloproteinase 2
(biosynthesis)
- Matrix Metalloproteinase 9
(biosynthesis)
- Matrix Metalloproteinases
(biosynthesis)
- Neoplasm Recurrence, Local
(enzymology, metabolism, pathology)
- Odontogenic Tumors
(enzymology, metabolism, pathology)
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