Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.

Abstract

AIM:

To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.

MATERIALS AND METHODS:

Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model.

RESULTS:

Five studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life.

CONCLUSION:

Adjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP.

REGISTRATION:

PROSPERO:

CRD42013006389.

• Authors: Caroline Moura Martins Lobo Santos, Ronaldo Lira-Junior, Ricardo Guimarães Fischer, Ana Paula Pires Santos, Branca Heloisa Oliveira
• Journal: PloS one (PLoS One) Vol. 10 Issue 12 Pg. e0145262 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26693909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (therapeutic use)
• Clinical Trials as Topic
• Databases, Factual
• Diabetes Complications (drug therapy)
• Diabetes Mellitus, Type 1 (drug therapy)
• Diabetes Mellitus, Type 2 (drug therapy)
• Female
• Humans
• Male
• Periodontitis (drug therapy, etiology)