[Leukinferon in the combined therapy of infection in neonates and infants].

Abstract

Leikinferon was used in multimodality treatment of sepsis caused by gram-negative microorganisms and staphylococci in 33 neonates and infants. It was injected in a dose of 10,000 IU and was given in courses of 4-6 intramuscular administrations with an interval of 48 hours. The treatment with leikinferon promoted a steady improvement of the clinical status, associated with pronounced activation of the interferon system and neutrophilic phagocytosis. The use of the drug in septic shock did not produce any noticeable affect. Fever was the only side effect induced by drug administration. In some children, the temperature rose by 1-1.5 degrees C. It returned to normal after 10-14 hours.

• Authors: G I Nizharadze, V P Kuznetsov, A Sh Gamkhitashvili, K G Chitaishvili, I V Pavlenishvili
• Journal: Pediatriia (Pediatriia) Issue 6 Pg. 46-9 ( 1989) ISSN: 0031-403X [Print] Russia (Federation)
• Vernacular Title: Leĭkinferon v kompleksnom lechenii sepsisa u novorozhdennykh i u deteĭ grudnogo vozrasta.
• PMID: 2668867 (Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Interferon Type I

Topics

• Age Factors
• Bacterial Infections (immunology, therapy)
• Drug Combinations
• Enterobacteriaceae Infections (immunology, therapy)
• Humans
• Infant
• Infant, Newborn
• Interferon Type I (therapeutic use)
• Male
• Serratia marcescens
• Staphylococcal Infections (immunology, therapy)
• Time Factors