Small Cell Lung Cancer Accompanied by Tonsillar Metastasis and Anti-Hu Antibody-Associated Paraneoplastic Neuropathy: A Rare Case Report With Long-Term Survival.

Abstract

Tonsillar metastatic small cell lung cancer (SCLC) is rare, while anti-Hu antibodies are frequently found in SCLC. A 66-year-old man was admitted to our hospital with painful dysesthesia and muscle weakness in the distal extremities for over 1 year, progressive dysphagia for over 1 month, and severe cough and dyspnea for over 1 week. He was diagnosed with SCLC accompanied by tonsillar metastasis and anti-Hu antibody-associated paraneoplastic sensory neuropathy (PSN). The patient tolerated 6 cycles of sequential chemoradiotherapy and gradually recovered. The patient's disease remained in remission 2 years after the diagnosis with a remarkable reduction of tumor burden and a persisting high titer of anti-Hu antibodies. To our knowledge, this is the first case of tonsillar metastatic SCLC accompanied by anti-Hu antibody-associated PSN, whereby the anticancer immune response was presumed to play a vital role in disease control. Unilateral tonsillar metastasis of SCLC accompanied by anti-Hu antibody-associated PSN can occur and in certain circumstances, may have a favorable prognosis.

• Authors: Jianjiao Ni, Linqian Weng, Mingsheng Liu, Hua Yang, Yingyi Wang
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 50 Pg. e2291 (Dec 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 26683964 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• ELAV Proteins

Topics

• Aged
• Antibodies (metabolism)
• ELAV Proteins (immunology)
• Humans
• Lung Neoplasms (immunology, metabolism, pathology)
• Male
• Paraneoplastic Polyneuropathy (complications, immunology, metabolism)
• Small Cell Lung Carcinoma (immunology, metabolism, secondary)
• Tonsillar Neoplasms (immunology, metabolism, secondary)